If you've found your way to this document
Perhaps you are somewhere at the beginning of all this. Maybe you're still in the thinking phase — turning the idea over, doing the research late at night, not quite ready to tell anyone. Or perhaps you want to get started and you're trying to work out what you're doing and why, and whether you're doing it right.
I know that place well.
Aged 43, I did two IVF cycles in 2024 — in Spain and then Greece — before conceiving naturally with a known donor met through a chance encounter, when I was aged almost 44. The donor had just turned 38 and was in relatively good health. I'd never previously tried to get pregnant, so I didn't have anything indicating my fertility other than a very low AMH.
When both IVF cycles failed, the doctors recommended I use a donor egg rather than trying with my own. One clinic in Spain even refused to treat me with my own eggs, asserting that a successful outcome was "improbable." I was devastated.
I wasn't ready to accept these diagnoses, which felt, to me, as though they were based primarily on my age. Yes I was older, but I didn't believe I was infertile. While donor eggs are a brilliant option that leads many women to their families, and I have a lot of respect for women who choose that path, I wasn't ready for this. I needed to feel that I'd really tried first, as much as I was able, with my own eggs.
I built Solo Fertility 40s because the resources I needed didn't exist or were hard to find online. What I struggled to find was honest, independent, non-commercial guidance on the parts of this process that aren't medical: how to choose a clinic, how to ask the right questions, how to protect yourself from an industry that might prioritise commercial gain over patient interests, and how to keep going when the process feels so overwhelmingly hard.
The timeline is shorter — the pressure is higher. Every decision lands on you alone, including the expensive ones. One income funding treatment, so there is no room to get it wrong. A system built for couples, navigated entirely by you.
I aim to provide the clarity and structure that would have made my fertility journey smoother, and less expensive. None of my work is sponsored. None of it is affiliated with any fertility clinic or service provider. I never earn commission or comment on medical matters, since I am trained in Eastern Medicine, not Western.
Wishing you the best — Sarah · hello@solofertility40s.com
Before you read
How to use this guide
Three things I'd like to be clear about:
- The supplements I took were specific to me and guided by my blood tests at the time and advice from my nutritionist. The vaginal microbiome test (ScreenMe) was also guided by my nutritionist.
- I'm not a doctor, nutritionist, or fertility expert.
- I became pregnant via a known donor I met through a chance encounter. This approach comes with risk and needs to be navigated with care. I never considered using apps that pair you with donors.
Unanswered questions. Becoming pregnant via natural conception with a known donor — on the first ovulation cycle — after two failed rounds of IVF and being recommended donor eggs has raised a few important questions. I am seeking medical input on them. Subscribe to Solo Fertility 40s to be notified when more detail becomes available.
Context
A word about donor eggs
Donor egg IVF is a remarkable option. For many women over 40, it is the path that leads to their family — and if that is your path, it is a brilliant one. The success rates are significantly higher than with your own eggs at this age, the process is well-established, and the children born through donor conception are wanted, loved, and entirely their parents' children in every way that matters.
What follows is a personal account of choosing a different route. I never want that to read as a criticism of women who choose egg donation, or as a suggestion that donor eggs are a lesser option. They are not.
The fertility industry has a complicated relationship with women over 40 who want to use their own eggs. Clinics monitor their success rates carefully, and a woman with low AMH in her mid-forties can be seen, bluntly, as a risk to those statistics. Being advised to move to donor eggs is not always a purely medical recommendation. Sometimes it is. Sometimes it is also a business decision. I say this not to be cynical, but because I believe you deserve to understand the full picture before you make one of the most important investments of your life.
What follows is a month-by-month account of the eighteen months between my first fertility results and the day I found out I was pregnant — naturally, on the first attempt, at almost 44, after two failed IVF cycles and two recommendations that I use donor eggs. You'll see that my journey included holistic approaches, which was inevitable because I'm a Shiatsu Practitioner and therefore already working with the mind-body connection.
Month by monthA Timeline of My Fertility Journey
I had a full set of fertility tests while on holiday in Goa, including Anti-Müllerian Hormone (AMH), the marker most commonly used to assess ovarian reserve.
I received the full picture. I was in Goa at the time — sitting in a cafe, I processed the meaning of the results, and cried.
My AMH read 2.2 pmol/L (or 0.31 ng/mL in the scale used by some clinics). Depending on who is reading it, this sits at the lower end of what is considered normal for a woman of 43 — and well below what many clinics like to see before proceeding with own-egg IVF.
I did not know yet what those numbers would mean for the road ahead. But the results were in, and the clock felt very loud. Holding out for Mr Right — a highly risky strategy — clearly wasn't working. I needed a new plan. I paid for a consultation with a clinic in Spain. Then despite the many red flags, moved forward and paid the deposit.
In June, I started taking DHEA (dehydroepiandrosterone) and omega 3.
DHEA is a hormone precursor that has been the subject of significant research in the context of poor ovarian response and low AMH. It is not a magic solution, and the evidence base is still developing — but it is one of the more studied supplements in this area, and I decided, after reading as much as I could, that it was worth trying.
The doctor at my first clinic, in Spain, suggested 75mg. That's a high dose, and wasn't suggested on the basis of any pre-testing. Around 10 weeks later, I stopped it because my skin was so greasy — worse than teenage acne — and my voice was developing a low tone.
I freaked out and realised I needed to hire a qualified nutritionist to understand exactly what I needed. Not simply what a book, or another woman, recommended.
Please speak to a doctor or qualified nutritionist before taking DHEA. It is not appropriate for everyone, dosage matters, and how your body responds will depend on factors specific to you.
At this point I was beginning to take active ownership of what I could actually influence — and that shift in orientation mattered as much as anything I was physically doing.
My first IVF cycle.
My protocol included 225 units of Pergoveris. I primed with birth control. I went to Spain and paid a well-established clinic 8,500 euros for a "Day 5 package with PGT-A." For medication, travel, accommodation and a few extras, I spent in total around 11,000 euros.
The cycle did not result in a pregnancy. The constant disorganisation, lack of patient care, and absence of empathy made this a traumatic experience. Worse, the doctor casually mentioned I use donor eggs, as if he was talking about the weather. I was shocked. There was nowhere to go with this confusion and grief. Once your cycle is over, clinics are typically no longer interested in supporting you.
IVF is physically demanding at any age. At 43, with low AMH, and flying abroad alone for treatment, it is also emotionally demanding in ways that are hard to fully prepare for — the combination of hope, medication, waiting, and uncertainty. I didn't have a strong support network.
After the Spain IVF cycle, I hired a BICA-accredited therapist.
BICA is the British Infertility Counselling Association — their members are trained specifically in fertility-related emotional support, which is a different discipline from general counselling. They understand the clinical context, the grief, what it means to have a cycle fail or to be told your odds are not good.
Hiring that therapist was critical in helping me heal and re-focus on my goal. The experience of a failed IVF cycle is not something you simply move on from. It needed to be properly addressed before I could approach the next phase from a grounded place.
In September I hired a nutritionist — Milena from Root & Leaf Nutrition, who I found through the Fertility Nutrition Centre. She specialises in fertility, and began a structured supplement protocol tailored specifically to me — my age, my blood results, my history. This was a significant step change from trying to DIY it, which I don't recommend. I wasted money on high street supplements that weren't potent or that I didn't need.
A supplement protocol should be tailored to your unique needs. My regime was designed for my specific hormonal picture, and reproducing it without proper assessment could be unhelpful or even counterproductive for someone with a different profile.
My supplement regime (from September 2024)
- Multi Essentials for Pregnancy
- Biome Her
- Proceive Omega 3
- Ubiquinol
- Magnesium (glycinate)
- NMN Capsules 250mg
- Ferrochel Iron Chelate
- Ashwagandha
- CherryActive Capsules (Montmorency Cherry Freeze Dried)
- Choline Bitartrate
- Vanilla protein and collagen shake
- Combination 12 tissue salts (prescribed by my homeopath)
The nutritionist also provided dietary guidance. A key aspect of this for me as a vegetarian was to increase my protein intake.
I also received Shiatsu, a gentle form of body and energy work. I again tried acupuncture but the needles are too uncomfortable.
My second IVF cycle, this time in Greece. Another difficult experience.
My protocol included 300 units of Meriofert and priming with low-dose Human Growth Hormone. I felt terrible and complained several times to my doctor but was dismissed. The cycle was a disaster. I had only one mature egg and it never fertilised. If I had done a scan before I left the UK, we might have chosen to cancel the cycle.
My body had been through a lot and I felt broken physically and mentally. Some weeks after the cycle I realised hair had fallen out around my temples. I had lower abdominal cramping that continued for around 8 weeks after the cycle.
I include this because it is part of the real story. The narrative around IVF — particularly for women who eventually conceive — can gloss over the hard parts in retrospect. The Greece cycle was genuinely rough.
Shortly after the cycle, I flew to India to recover. I needed to be somewhere warm, restorative, and familiar.
Rest as a deliberate, intentional act is underrated in the fertility conversation. We talk a great deal about doing — supplements, protocols, cycles, interventions. We talk much less about the value of stopping, for a period, and letting the body settle. This was that period for me.
December was when things shifted most significantly, and it is the month I find hardest to summarise neatly — because several things changed.
Following my own research, I started taking Low Dose Naltrexone (LDN) that I purchased in Athens. LDN is a medication with a growing body of interest in the context of autoimmune conditions and, more recently, fertility. The evidence base is still relatively early. I was not taking it under medical guidance.
Beyond the medication, December was also about returning to something more fundamental. I was in India, eating vegetable-rich food, getting morning sunshine every day, swimming in the sea, walking barefoot. These things sound almost simple set next to the clinical complexity of IVF. I include them because they were significant in both my recovery and my preparation for more IVF cycles.
I also worked deliberately on my mindset. I had spent months inside a framework that positioned my body as failing, as unlikely, as past it. I wanted to find my way back to a different relationship with it — one that assumed capability rather than deficit. I read Paul McKenna's Power Manifesting and did the exercises it outlines.
I also wrote a little mantra to help change my very negative mindset about my ability to become pregnant. It made it much easier to be around children and to experience all the new life surrounding me as a positive feeling. Previously I'd run out of shops or crossed the road to avoid small children and pregnant women. My outlook brightened.
"Fertility is all around and within."
By January, I had made a decision: I was going back to Greece, to a clinic called Embryolab, and I committed to undertaking three more IVF cycles. This was not a decision made in desperation — it came from a place of having done a significant amount of physical and emotional work over the preceding months.
Having a clear plan, and a doctor I trusted, mattered more than I had anticipated. The sense of direction was itself stabilising.
The healthy eating continued. I reduced toxins such as sugar, except for in fruit, and kept up my protein levels. I walked, swam, hit the yoga mat, worked on my mindset.
In February, I had a chance encounter with a man who offered to be a sperm donor.
I want to be careful about how I describe this, because every woman's circumstances are different and the decisions around donor conception are deeply personal. I got to know him and somehow it felt right to try.
Not everyone will have this experience — most women pursuing solo fertility treatment use anonymous or identity-release donors through licensed sperm banks, which is a well-supported and well-documented route. If you are considering your options around donors, the Donor Conception Network (dcnetwork.org) offers excellent independent guidance.
In March, using a natural ovulation cycle, I made a first attempt at pregnancy with this known donor.
After two IVF cycles and everything that had gone into them — the protocols, the medications, the monitoring, the waiting — the simplicity of it felt almost disorienting. I worked with a local gynaecologist to be clear about my ovulation window. The scans and consults under his care were the first feeling of empathy and support I experienced from a medical expert.
Sitting in Goa again — the same stretch of coastline where, a year earlier, I had cried reading my AMH results — I took a pregnancy test. It was a cheap one from a local pharmacy but there was no doubt: it was positive.
This was on my first attempt at pregnancy, ever, aged almost 44, after two doctors said my only chance of a baby was via a donor egg.
The pregnancy was uncomplicated in medical terms — though anxiety, given everything I had been through, was a challenge. I do not think that is unusual for women who have had difficult treatment histories. The physical ease of the pregnancy did not automatically translate into emotional ease.
On December 23rd, 2025, my daughter arrived by emergency caesarean section at 39 weeks and six days.
What I want you to take from this
My story isn't a protocol, a promise, or a prescription. It is an account of what one woman did, across eighteen months, that preceded a pregnancy she had been told was unlikely.
Everything here reflects my own personal experience and should not be taken as medical guidance of any kind. Please seek qualified medical input for all decisions relating to your fertility and health.
There is a broader conversation worth having about when and how women over 40 are advised — or pressured — to move to donor eggs. Some of those conversations are genuinely well-intentioned and medically sound. Others are influenced by factors that have more to do with clinic success rates than with your individual prognosis. Knowing the difference matters.
If you feel uncertain about donor eggs — if you are not sure whether you are ready, or whether you have truly exhausted your own options — you are allowed to take time with that decision. You are not obliged to rush, even if that's encouraged by your clinic.
Reference
A Summary of What I Was Doing
Supplements — as prescribed by Root & Leaf Nutrition
Daily (from September 2024)
- Multi Essentials for Pregnancy
- Biome Her
- Proceive Omega 3
- Magnesium (glycinate)
- NMN Capsules 250mg
- Ferrochel Iron Chelate
- Ashwagandha
- CherryActive Capsules (Montmorency Cherry)
- Choline Bitartrate
- Vanilla protein and collagen shake
- Combination 12 tissue salts (homeopathic)
Earlier supplements (June – August 2024 only)
- DHEA 75mg (stopped due to side effects)
- Omega 3
Added December 2024 (based on personal research, not medical guidance)
- Low Dose Naltrexone (LDN)
IVF Medications and Protocols
- Spain, July 2024: 225 units Pergoveris · Birth control priming · PGT-A testing
- Greece, November 2024: 300 units Meriofert · Low-dose Human Growth Hormone priming
Mind and Body — Holistic Approaches
- BICA-accredited fertility therapist (from August 2024)
- Shiatsu treatments
- Daily mantra: "fertility is all around and within"
- Paul McKenna's Power Manifesting exercises
- Meditation
- Daily walking, swimming, yoga
- Morning sunshine exposure (daily, in India)
- Walking barefoot
- Vegetable-rich, high-protein diet (as vegetarian)
- Reduced sugar (except from fruit)
- Three-month recovery stay in India after the second failed cycle
- Intentional rest periods throughout
Further support
Independent Guidance and Resources
BICA (British Infertility Counselling Association) — bica.net — lists accredited therapists who specialise in fertility, donor conception, and solo motherhood.
The Donor Conception Network — dcnetwork.org — offers independent guidance, community, and resources for people considering or navigating donor conception.
Single Mothers by Choice (SMBC) — singlemothersbychoice.org — has a long-established community of women navigating solo fertility and solo motherhood.
solofertility40s.com — honest writing, from inside the experience, about what solo women over 40 actually need to know before and during fertility treatment. No clinic affiliations or sponsored content. Over 80 articles, read by +280 women across 37 countries.
Important
Disclaimer
This document has been created and shared by Solo Fertility 40s for informational purposes only. It reflects one individual's personal experience and is not intended as medical advice of any kind.
I am not a doctor, nurse, pharmacist, nutritionist, or any other regulated healthcare professional. Nothing in this document should be taken as a recommendation to start, stop, or adjust any treatment, medication, or supplement.
Fertility treatment is a complex medical field and outcomes depend on a wide range of individual factors. The fact that I conceived naturally at 43 does not mean that a similar outcome is probable, possible, or likely for any individual reader. Every woman's fertility picture is different.
Specific medications and supplements mentioned in this document — including DHEA and Low Dose Naltrexone (LDN) — should only be taken under proper medical supervision after consultation with a qualified healthcare professional. Neither the author nor Solo Fertility 40s accepts any responsibility for decisions made based on the content of this document.
If you are considering fertility treatment, please seek personalised advice from a licensed medical professional. If you are struggling emotionally with fertility-related experiences, please reach out to a qualified therapist, preferably one accredited by BICA or an equivalent body.
This document is free to share in its original, unedited form. It may not be reproduced in part, altered, or used for commercial purposes without permission.